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Nano Biomaterials - Graphene Oxide
Dec 28, 2018

In recent years, the flourishing development of nanoscience has greatly accelerated the transformation of various nanomaterials in living organisms. Exploring the potential interactions between nanomaterials and bioenvironmental components to reveal their opportunities and limitations has become a key issue in the development of nanobiomaterials and the control of their biological effects. Graphene Oxide is an oxidized derivative of graphene which contains a hydroxyl group and an epoxy group at the center of the sheet structure and a carboxyl group at the edge of the sheet structure. These oxygen-containing functional groups not only incubate the excellent aqueous dispersion of graphene oxide, but also provide a large number of functionalization sites. These properties make graphene oxide a biomaterial that is promising in many fields. Therefore, an in-depth understanding of how graphene oxide interacts with biological components plays an extremely important role in its future development in the biological and medical fields.

Recently, Jiang Xiuyan, a research group of the Changchun Institute of Applied Chemistry of the Chinese Academy of Sciences, based on the previous research, used a carboxyl-terminal self-assembled monolayer to simulate biomolecules and formed a potential Bronsted acid-base pair with graphene oxide. Surface enhanced infrared spectroscopy explores the proton transfer between the two. Through in-depth analysis of graphene oxide-induced self-assembled monolayer interface water and characteristic carbon-based vibration peaks, they found that graphene oxide can adsorb to the self-assembled monolayer surface and protonate the monolayer film. Surprisingly, the ability of this protonated monolayer does not disappear with the increase in buffer capacity of the system, and the behavior of small organic acids such as formic acid is completely different. Graphene oxide is a two-dimensional lamellar structure with a single atomic thickness. The ionizable acidic groups in the oxygen-containing functional groups are located on adjacent or conjugated carbon atoms and have different microenvironments to affect each other's ionization. For graphene oxide sheets in aqueous solution, partially dissociated protons diffuse into the bulk solution to make the graphene oxide aqueous solution acidic, and partially dissociated protons bound to the graphene oxide/water interface. These oxygen-containing functional groups in turn oxidize the excellent proton conductivity of graphene oxide. Due to the ultra-thin two-dimensional structure of graphene oxide, the dissociated protons at the graphene oxide/water interface form weak hydrogen bonds with water molecules bound to the surface of the graphene oxide and closely adjacent oxygen-containing functional groups, thereby continuously reconstituting these Hydrogen bonding is conducted on the plane of the sheet of graphene oxide. Therefore, the authors propose that the natural acidity and high proton conductivity of graphene oxide make graphene oxide appear as a two-dimensional exchangeable proton pool in solution, which can be dissociated and transferred when a suitable Bronsted base exists at the interaction interface. Proton. For graphene oxide and carboxyl terminated self-assembled monolayer systems, in addition to lowering the pH of the bulk of the solution, graphene oxide can transfer protons at the interface of the graphene oxide/water/self-assembled monolayer film. The authors also systematically investigated the effect of interfacial proton density and proton conductivity on the proton transfer at the graphene oxide interface. This work not only greatly enhanced the understanding of the nano-bio interface, but also suggested that interfacial proton transfer may be a neglected source of bioavailability of graphene oxide.

Graphene Oxide

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